DEP-Dots for 3D cell culture

pharmacodane

DEP-Dots for 3D cell culture: low-cost, high-repeatability, effective 3D cell culture in multiple gel systems

It is known that cells grown in 3D are more tolerant to drug treatment than those grown in dispersion, but the mechanism for this is still not clear; cells grown in 3D have opportunities to develop inter-cell communication, but are also closely packed which may impede diffusion.
In this study we examine methods for dielectrophoresis-based cell aggregation of both suspension and adherent cell lines, and compare the effect of various drugs on cells grown in 3D and 2D. Comparing viability of pharmacological interventions on 3D cell clusters against both suspension cells and adherent cells grown in monolayer, as well as against a unicellular organism with no propensity for intracellular communication, we suggest that 3D aggregates of adherent cells, compared to suspension cells, show a substantially different drug response to cells grown in monolayer, which increases as the IC50 is approached.
Further, a mathematical model of the system for each agent demonstrates that changes to drug response are due to inherent changes in the system of adherent cells from the 2D to 3D state. Finally, differences in the electrophysiological membrane properties of the adherent cell type suggest this parameter plays an important role in the differences found in the 3D drug response.
pharmacodane

pharmacodane

rHu MIP-4

AK8218-1000 1mg Ask for price

rHu MIP-3-beta

AK8232-0005 5µg Ask for price

rHu MIP-3-beta

AK8232-0020 20µg Ask for price

rHu MIP-3-beta

AK8232-0100 100µg Ask for price

rHu MIP-3-beta

AK8232-1000 1mg Ask for price

rHu MIP-1-alpha

AK8250-0005 5µg Ask for price

rHu MIP-1-alpha

AK8250-0020 20µg Ask for price

rHu MIP-1-alpha

AK8250-0100 100µg Ask for price

rHu MIP-1-alpha

AK8250-1000 1mg Ask for price

rHu MIP-1-beta

AK8264-0002 2µg Ask for price

rHu MIP-1-beta

AK8264-0010 10µg Ask for price

rHu MIP-1-beta

AK8264-0100 100µg Ask for price

rHu MIP-1-beta

AK8264-1000 1mg Ask for price

rHu MIP-3-alpha

AK8271-0005 5µg Ask for price

rHu MIP-3-alpha

AK8271-0020 20µg Ask for price

rHu MIP-3-alpha

AK8271-0100 100µg Ask for price

rHu MIP-3-alpha

AK8271-1000 1mg Ask for price

rHu IL-4

AK8329-0005 5µg Ask for price

rHu IL-4

AK8329-0020 20µg Ask for price

rHu IL-4

AK8329-0100 100µg Ask for price

rHu IL-4

AK8329-1000 1mg Ask for price

rHu MCP-4

AK8332-0005 5µg Ask for price

rHu MCP-4

AK8332-0020 20µg Ask for price

rHu MCP-4

AK8332-0100 100µg Ask for price

rHu MCP-4

AK8332-1000 1mg Ask for price

rHu FGF-4

AK9698-0005 5µg Ask for price

rHu FGF-4

AK9698-0025 25µg Ask for price

rHu FGF-4

AK9698-0100 100µg Ask for price

rHu FGF-4

AK9698-1000 1mg Ask for price

rHu IL-4 (cGMP)

AK9839-0000 1mg Ask for price

rHu IL-4 (cGMP)

AK9839-0100 100ug Ask for price

rHu BMP-4 (CHO)

AK9996-0005 5µg Ask for price

rHu BMP-4 (CHO)

AK9996-0020 20µg Ask for price

rHu BMP-4 (CHO)

AK9996-0100 100µg Ask for price

rHu BMP-4 (CHO)

AK9996-1000 1mg Ask for price

MIP-4/CCL18, Human

HY-P7265 50ug
EUR 533

MIP-4 (PARC), human recombinant

4257-10
EUR 338

MIP-4 (PARC), human recombinant

4257-1000
EUR 5917

Human MIP-4 ELISA Kit

EHM0021 96Tests
EUR 521

Bovine MIP-4 ELISA Kit

EBM0021 96Tests
EUR 521

Chicken MIP-4 ELISA Kit

ECKM0021 96Tests
EUR 521

Anserini MIP-4 ELISA Kit

EAM0021 96Tests
EUR 521

Canine MIP-4 ELISA Kit

ECM0021 96Tests
EUR 521

Goat MIP-4 ELISA Kit

EGTM0021 96Tests
EUR 521

Porcine MIP-4 ELISA Kit

EPM0021 96Tests
EUR 521

Sheep MIP-4 ELISA Kit

ESM0021 96Tests
EUR 521

Rat MIP-4 ELISA Kit

ERM0021 96Tests
EUR 521

Rabbit MIP-4 ELISA Kit

ERTM0021 96Tests
EUR 521

Monkey MIP-4 ELISA Kit

EMKM0021 96Tests
EUR 521

Mouse MIP-4 ELISA Kit

EMM0021 96Tests
EUR 521

MIP-4, PARC, CCL18, human

RC315-29 2ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Guinea Pig MIP-4 ELISA Kit

EGM0021 96Tests
EUR 521

Recombinant Human MIP-4 (CCL18) Protein

PROTP55774-2 10ug
EUR 317
Description: MIP-4 is a CC chemokine that is expressed in lymph nodes, lungs, placenta and bone marrow. MIP-4's primary receptor is unknown. MIP-4 chemoattracts lymphocytes, and has been shown to exert activity on both CD4+ and CD8+ T cells. Recombinant human MIP-4 is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

IL-4 Interleukin 4 Human Recombinant Protein, Yeast

PROTP05112-4 Regular: 10ug
EUR 317
Description: Interleukin-4 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 129 amino acids.;The IL-4 is purified by proprietary chromatographic techniques.

Individual Reaction Mix 4

G065-4 200 reactions
EUR 167

rHu Insulin

AK8211-0025 25mg Ask for price

rHu Insulin

AK8211-0250 250mg Ask for price

rHu Insulin

AK8211-1000 1g Ask for price

rHu aFGF

AK8230-0010 10µg Ask for price

rHu aFGF

AK8230-0050 50µg Ask for price

rHu aFGF

AK8230-0100 100µg Ask for price

rHu aFGF

AK8230-1000 1mg Ask for price

rHu MCSF

AK8238-0002 2µg Ask for price

rHu MCSF

AK8238-0010 10µg Ask for price

rHu MCSF

AK8238-0100 100µg Ask for price

rHu MCSF

AK8238-1000 1mg Ask for price

rHu CTGF

AK8240-0005 5µg Ask for price

rHu CTGF

AK8240-0020 20µg Ask for price

rHu CTGF

AK8240-0100 100µg Ask for price

rHu CTGF

AK8240-1000 1mg Ask for price

rHu MIF

AK8255-0005 5µg Ask for price

rHu MIF

AK8255-0025 25µg Ask for price

rHu MIF

AK8255-0100 100µg Ask for price

rHu MIF

AK8255-1000 1mg Ask for price

rHu Myostatin

AK8256-0002 2µg Ask for price

rHu Myostatin

AK8256-0010 10µg Ask for price

rHu Myostatin

AK8256-0100 100µg Ask for price

rHu Myostatin

AK8256-1000 1mg Ask for price

rHu Leptin

AK8265-0200 200µg Ask for price

rHu Leptin

AK8265-1000 1mg Ask for price

rHu Leptin

AK8265-5000 5mg Ask for price

rHu RANTES

AK8275-0005 5µg Ask for price

rHu RANTES

AK8275-0020 20µg Ask for price

rHu RANTES

AK8275-0100 100µg Ask for price

rHu RANTES

AK8275-1000 1mg Ask for price

rHu BDNF

AK8286-0002 2µg Ask for price

rHu BDNF

AK8286-0010 10µg Ask for price

rHu BDNF

AK8286-0100 100µg Ask for price

rHu BDNF

AK8286-1000 1mg Ask for price

rHu CNTF

AK8302-0005 5µg Ask for price

rHu CNTF

AK8302-0020 20µg Ask for price

rHu CNTF

AK8302-0100 100µg Ask for price

rHu CNTF

AK8302-1000 1mg Ask for price

rHu EGF

AK8327-0100 100µg Ask for price

rHu EGF

AK8327-0500 500µg Ask for price

rHu EGF

AK8327-1000 1mg Ask for price

rHu GDNF

AK8335-0002 2µg Ask for price

rHu GDNF

AK8335-0010 10µg Ask for price

rHu GDNF

AK8335-0100 100µg Ask for price

Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults

Humanin (HN) is a 24-amino acid mitochondrial-derived peptide, best known for its ability to protect neurons from damage caused by ischemic stroke and neurodegenerative insults and cardiomyocytes from myocardial infarction or doxorubicin (Dox)-induced cardiotoxicity.
This study examines the neuroprotective and myoprotective effects of HN novel synthetic analogs HUJInin and c(d-ser14)HN, prepared by solid-phase peptide synthesis. The cellular models employed were oxygen-glucose-deprivation (OGD) followed by reoxygenation (R)-induced neurotoxicity in PC12 and SH-SY5Y neuronal cell cultures and Dox-induced cardiotoxicity in H9c2 and C2C12 myoblast cell cultures, respectively.
Necrotic and apoptotic cell death was measured by LDH release and caspase-3 activity. Erk 1/2 and AKT phosphorylations were examined by western blotting. Mitochondrial calcium and mitochondrial membrane potential were measured using the fluorescent dye tetramethylrhodamine-methyl ester. It was found that HUJInin and c(d-ser14)HN conferred significant dose-dependent neuroprotection, a phenomenon related to attenuation of OGD insult-induced Erk 1/2 phosphorylation, stimulation of AKT phosphorylation and improvement of mitochondrial functions.
These peptides also conferred myoprotective effect towards (Dox)-induced apo-necrotic cell death insults. HUJInin and c(d-ser14)HN synthetic analogs may provide new lead compounds for the development of a potential candidate drug for stroke treatment and/or DOX-induced cardiotoxicity therapy in cancer patients.

Enhancing the Furosemide Permeability by Papain Minitablets Through a Triple Co-culture In Vitro Intestinal Cell Model

The administration of medicines by the oral route is the most used approach for being very convenient. Although it is the most popular, this route also has absorption, and consequently, bioavailability limitations. In this sense, several pharmacotechnical strategies have been used to improve drug absorption, one of which is the use of permeation promoters.
Papain is a very versatile plant enzyme that can be used as a permeation promoter of various active compounds. This study aimed to evaluate the safety of papain and the formulation of native papain minitablets to promote in vitro permeation of furosemide through an innovative biomimetic triple co-culture model of Caco-2, HT29-MTX, and Raji cells.
Regarding permeation, furosemide and metaprolol concentrations are determined with HPLC; those are used to calculate Papp. Monolayer integrity was evaluated using TEER and Lucifer Yellow. In the presence of papain, TEER decreased two-fold and the Papp of furosemide increased six-fold.
The results suggest that native papain minitablets can be used as therapeutic adjuvants to enhance the permeation of drugs significantly improving bioavailability.

MIP-3-beta/CCL19, Mouse

HY-P7264 50ug
EUR 533

anti- MIP-3-beta antibody

FNab05194 100µg
EUR 505.25
  • Immunogen: chemokine(C-C motif) ligand 19
  • Uniprot ID: Q99731
  • Research Area: Immunology, Signal Transduction
Description: Antibody raised against MIP-3-beta

Anti-MIP-3-beta antibody

PAab05194 100 ug
EUR 355

MIP-3 beta, CCL19, murine (mouse)

RC335-20 5ug
EUR 101.33
  • Product category: Proteins/Recombinant Proteins/Cytokines

MIP 1 beta antibody

20R-1789 100 ug
EUR 673
Description: Rabbit polyclonal MIP 1 beta antibody

MIP-1-beta Antibody

5249-100
EUR 338

rHu MIP-1-beta

AK8264-0002 2µg Ask for price

rHu MIP-1-beta

AK8264-0010 10µg Ask for price

rHu MIP-1-beta

AK8264-0100 100µg Ask for price

rHu MIP-1-beta

AK8264-1000 1mg Ask for price

Anti-MIP- beta antibody

STJ94131 200 µl
EUR 197
Description: Rabbit polyclonal to MIP-3beta.

Anti-MIP- beta antibody

STJ96572 200 µl
EUR 197
Description: Rabbit polyclonal to MIP-1beta.

rM IL-2

AK8323-0005 5µg Ask for price

rM IL-2

AK8323-0020 20µg Ask for price

rM IL-2

AK8323-0100 100µg Ask for price

rM IL-2

AK8323-1000 1mg Ask for price

Human CCL19/MIP-3 beta ELISA Kit

LF-EK50840 1×96T
EUR 648

Recombinant Human MIP-3 Beta (CCL19) Protein

PROTQ99731-1 20ug
EUR 317
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Recombinant Murine MIP-3 Beta (CCL19) Protein

PROTO70460-2 20ug
EUR 317
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant murine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-3

EF016984 96 Tests
EUR 689

MIP-3

EF017888 96 Tests
EUR 689

MIP-3

EF013760 96 Tests
EUR 689

MIP-3

EF013761 96 Tests
EUR 689

MIP-3

EF016652 96 Tests
EUR 689

MIP-3

EF010865 96 Tests
EUR 689

MIP-3

EF012726 96 Tests
EUR 689

MIP-3

PAab09791 100 ug
EUR 386

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody

M02431-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

1 mm Gaskets 3/pk, RM

2398237 5unit
EUR 257

MIP-1-beta/CCL4, Human

HY-P7257 10ug
EUR 268

MIP-1 beta, CCL4, human

RC314-15 2ug
EUR 101.33
  • Product category: Proteins/Recombinant Proteins/Cytokines

MIP-1 beta, CCL4, rat

RC355-15 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

ELISA kit for Human CCL19/MIP-3 Beta

EK5194 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CCL19/MIP-3 Beta in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Mouse CCL19/MIP-3 beta

EK5195 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse CCL19/MIP-3 beta in samples from serum, plasma, tissue homogenates and other biological fluids.

Human CCL19/MIP-3 beta PicoKine ELISA Kit

EK0456 96 wells
EUR 425
Description: For quantitative detection of human CCL19 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Mouse CCL19/MIP-3 beta PicoKine ELISA Kit

EK0457 96 wells
EUR 425
Description: For quantitative detection of mouse CCL19 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Rabbit Anti Human Mip-3 Beta Polyclonal Antibody

CPBT-65218RH 0.1 mg
EUR 881

Anti-CCL19/Mip 3 Beta Rabbit Monoclonal Antibody

M01605 100ug/vial
EUR 397
Description: Rabbit Monoclonal CCL19/Mip 3 Beta Antibody. Validated in WB and tested in Human.

Clips 4/pk RM

2398239 6unit
EUR 250

1mm Pressure Platen - RM

2398242 3unit
EUR 281

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

anti- MIP-3

LSMab09791 100 ug
EUR 386

GRO-beta/MIP-2, rat recombinant

4108-1000
EUR 3965

GRO-beta/MIP-2, rat recombinant

4108-20
EUR 262

MIP-2/Gro-beta, murine recombinant

4251-1000
EUR 5204

MIP-2/Gro-beta, murine recombinant

4251-20
EUR 297

GRO beta / MIP-2 (CXCL2) Protein

20-abx261572
  • EUR 328.00
  • EUR 3418.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

GRO beta / MIP-2 (CXCL2) Protein

20-abx261590
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

GRO beta / MIP-2 (CXCL2) Protein

20-abx261604
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Pig MIP-1 Beta (CCL4) Protein

abx670310-5ug 5 ug
EUR 411
  • Shipped within 1 week.

MIP-1 beta (human) ELISA Kit

K4785-100 100 assays
EUR 809
  • Kit components:
  • MIP-1 β antibody-coated Microplate (Item A), 96 wells
  • Wash Buffer (20x) (Item B)
  • rh MIP-1 β Standards (Item C)
  • Assay Diluent A (Item D)
  • Assay Diluent B (5x) (Item E)
  • MIP-1 β Detection Antibody (Item F)
  • HRP-St
  • Show more
Description: Sensitive, Colorimetric Assay

MIP-1 beta, CCL4, murine (mouse)

RC335-15 2ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Rabbit Anti Human Mip-3 Beta Polyclonal Antibody,Biotin

CPBT-65217RH 50 µg
EUR 881

Anti-IL1 beta Antibody

A00101-3 100ug
EUR 455
Description: Rabbit Polyclonal IL1 beta Antibody. Validated in IP, IF, IHC, WB and tested in Mouse, Rat.

1 mm Preparative Comb, RM

2328934 3unit
EUR 253
Description: 1 sampl e wel l and 1 r efer ence wel l

0.75mm Plate Set,RM-075

2393014 2unit
EUR 263
Description: 1 pai r of gl ass pl at es + 1 gask et , for 0.75 mm gel

5 mm Dummy Plate, RM

2393074 10unit
EUR 241
Description: Pl ast i c pl at e for r unni ng 1 Pagel pr ecast gel onl y

2mm Plate Set,RM-22

2393740 3unit
EUR 281
Description: 1 pai r of gl ass pl at es + 1 gask et , for 2 mm gel

7 mm Dummy Plate, RM

2398247 10unit
EUR 241
Description: Pl ast i c pl at e for r unni ng 1 hand-cast gel onl y

1 mm Blank Comb, RM

2399041 4unit
EUR 272

Anti-GLB1/Beta-galactosidase Antibody

A01829-3 100ug/vial
EUR 334

Anti- Beta-tubulin Monoclonal Antibody

M05613-3 100ul
EUR 397
Description: Mouse Monoclonal Beta-tubulin Antibody. Validated in IHC, WB and tested in Human, Monkey, Mouse, Rat.

Recombinant Human IFN-Beta Protein

PROTP01574-3 20ug
EUR 317
Description: Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFNα is an acid stable molecule that signals through IFNα/βR, which is also used by IFNβ. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFNα contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant human IFNβ is an 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFNβ has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry.

*Human IFN-β(Catalog Number 300-02BC) has replaced Human IFN-β(Catalog Number 300-02B)

Swine IFN beta Recombinant Protein

R02041-3 5ug/vial
EUR 259
Description: IFN beta is a mammalian Type I interferon, functioning as a regulator of cellular activity by interacting with cell-surface receptors and activating various signaling pathways. IFN beta produces antiviral, antibacterial, and anticancer properties. Swine IFN beta Recombinant Protein is purified IFN beta produced in yeast.

Recombinant Human GRO-beta/MIP-2 (CXCL2)

7-01864 2µg Ask for price

Recombinant Human GRO-beta/MIP-2 (CXCL2)

7-01865 10µg Ask for price

Recombinant Human GRO-beta/MIP-2 (CXCL2)

7-01866 1mg Ask for price

Recombinant Mouse GRO-beta/MIP-2 (CXCL2)

7-01870 5µg Ask for price

Recombinant Mouse GRO-beta/MIP-2 (CXCL2)

7-01871 20µg Ask for price

Recombinant Mouse GRO-beta/MIP-2 (CXCL2)

7-01872 1mg Ask for price

Recombinant Rat GRO-beta/MIP-2 (CXCL2)

7-01873 5µg Ask for price

Recombinant Rat GRO-beta/MIP-2 (CXCL2)

7-01874 20µg Ask for price

Recombinant Rat GRO-beta/MIP-2 (CXCL2)

7-01875 1mg Ask for price

GRO beta / MIP-2 (CXCL2) His Protein

20-abx260689
  • EUR 328.00
  • EUR 3418.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Human CCL4/MIP-1 beta ELISA Kit

LF-EK50838 1×96T
EUR 648

Rat CCL4/MIP-1 beta ELISA Kit

LF-EK50964 1×96T
EUR 648

Recombinant Rat MIP-1 Beta (CCL4) Protein

PROTP50230-1 20ug
EUR 317
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant rat MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Recombinant Human MIP-1 Beta (CCL4) Protein

PROTQ8NHW4-2 10ug
EUR 317
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant human MIP-1βis a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Recombinant Murine MIP-1 Beta (CCL4) Protein

PROTP14097-1 10ug
EUR 317
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant murine MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Mouse MIP-1-beta/CCL4 ELISA Kit

RK00072 96 Tests
EUR 521

Human MIP-1-beta/CCL4 ELISA Kit

RK00138 96 Tests
EUR 521

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-100ug

QP10273-ec-100ug 100ug
EUR 988

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-20ug

QP10273-ec-20ug 20ug
EUR 290

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-250ug

QP10273-ec-250ug 250ug
EUR 1731

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-5ug

QP10273-ec-5ug 5ug
EUR 154

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-1mg

QP5219-1mg 1mg
EUR 2856

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-500ug

QP5219-500ug 500ug
EUR 1778

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-100ug

QP5258-100ug 100ug
EUR 490

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-1mg

QP5258-1mg 1mg
EUR 2856

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-20ug

QP5258-20ug 20ug
EUR 237

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-500ug

QP5258-500ug 500ug
EUR 1778

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-5ug

QP5258-5ug 5ug
EUR 136

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-100ug

QP8024-ec-100ug 100ug
EUR 408

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-10ug

QP8024-ec-10ug 10ug
EUR 200

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-1mg

QP8024-ec-1mg 1mg
EUR 1632

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-200ug

QP8024-ec-200ug 200ug
EUR 634

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-500ug

QP8024-ec-500ug 500ug
EUR 1060

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-50ug

QP8024-ec-50ug 50ug
EUR 263

rHu MIP-3-alpha

AK8271-0005 5µg Ask for price

rHu MIP-3-alpha

AK8271-0020 20µg Ask for price

rHu MIP-3-alpha

AK8271-0100 100µg Ask for price

rHu MIP-3-alpha

AK8271-1000 1mg Ask for price

MIP-3? Polyclonal Antibody

ES8712-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MIP-3? from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MIP-3? Polyclonal Antibody

ES8712-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MIP-3? from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MIP-3? Polyclonal Antibody

ES7130-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MIP-3? from Human. This antibody is tested and validated for IHC, WB, ELISA

MIP-3? Polyclonal Antibody

ES7130-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MIP-3? from Human. This antibody is tested and validated for IHC, WB, ELISA

MIP-3, CCL23, human

RC315-34 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Anti-beta 2 Microglobulin/B2m Antibody

A00456-3 100ug/vial
EUR 294

Anti-Beta Tubulin Antibody (monoclonal, 5E4)

M01857-3 100ug/vial
EUR 294

Recombinant Human IL-1 Beta Protein

PROTP01584-3 10ug
EUR 317
Description: IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Equine IL-1 beta Recombinant Protein

R00101-3 5ug/vial
EUR 259
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Equine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Recombinant Human TNF-Beta (E.coli-derived) Protein

PROTP01374-3 20ug
EUR 317
Description: TNF-β is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-α. Like TNF-α, TNF-β is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β, which effectively anchors the TNF-β to the cell surface. TNF-β is cytotoxic to a wide range of tumor cells. Recombinant human TNF-β is a secreted 171 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.

Mip/ Rat Mip ELISA Kit

ELI-23038r 96 Tests
EUR 886

1 mm 6-well Comb, RM

2328375 3unit
EUR 255

1 mm 8-well Comb, RM

2328376 3unit
EUR 255

1 mm 20-well Comb, RM

2328422 3unit
EUR 311

1 mm 10-well Comb, RM

2328948 3unit
EUR 288

A-M310 agarGEL RM, 10/pk

2332200 2unit
EUR 351
Description: pH 3 - 10

A-M38 agarGEL RM, 10/pk

2332210 2unit
EUR 351
Description: pH 3 - 8

A-M58 agarGEL RM, 10/pk

2332220 2unit
EUR 351
Description: pH 5 - 8

A-M510 agarGEL RM, 10/pk

2332230 2unit
EUR 351
Description: pH 5 - 10

1 mm Plate Set, RM-10

2398214 3unit
EUR 281
Description: 1 pai r of gl ass pl at es + 1 gask et , for 1 mm gel

0.75mm Glass plates 2/pk,RM

2398228 2unit
EUR 279
Description: N ot ched pl at e wi t h 0.75mm si de-spacer s

2mm Glass plates 2/pk, RM

2398236 2unit
EUR 249
Description: N ot ched pl at e wi t h 2mm si de-spacer s

0.75mm 12-well Combs 2pk,RM

2398271 2unit
EUR 269

MIP-3b Macrophage Inflammatory Protein-3 Beta Human Recombinant Protein (CCL19)

PROTQ99731 Regular: 20ug
EUR 317
Description: Macrophage Inflammatory Protein-3 beta Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.8kDa. ;The MIP-3b is purified by proprietary chromatographic techniques.

MIP-3b Macrophage Inflammatory Protein-3 Beta Mouse Recombinant Protein (CCL19)

PROTO70460 Regular: 20ug
EUR 317
Description: Macrophage Inflammatory Protein-3 beta Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9216 Dalton. ;The MIP-3b is purified by proprietary chromatographic techniques.

Recombinant Human TGF-Beta 2 (mammalian derived) Protein

PROTP61812-3 10ug
EUR 317
Description: The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

ELISA kit for Human CCL4/MIP-1 Beta

EK5189 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CCL4/MIP-1 Beta in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat CCL4/MIP-1 Beta

EK5423 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat CCL4/MIP-1 Beta in samples from serum, plasma, tissue homogenates and other biological fluids.

Human CCL4/MIP-1 beta PicoKine ELISA Kit

EK0450 96 wells
EUR 425
Description: For quantitative detection of human CCL4 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Rat CCL4/MIP-1 beta PicoKine ELISA Kit

EK0939 96 wells
EUR 425
Description: For quantitative detection of rat CCL4 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Rabbit Anti Human Mip-1 Beta Polyclonal Antibody

CPBT-65212RH 0.1 mg
EUR 881

GRO-beta/MIP-2 Rat Recombinant Protein (CXCL2)

PROTP30348 Regular: 20ug
EUR 317
Description: GRO-Beta Rat Recombinant also called Rat MIP-2 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7923 Dalton. ;The GRO-b is purified by proprietary chromatographic techniques.

Recombinant Rat GRO-Beta /MIP-2 (CXCL2) Protein

PROTP30348-1 25ug
EUR 317
Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO-β/MIP-2 is a 7.9 kDa protein consisting of 73 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Recombinant (E.Coli) Human GRO-beta/MIP-2 (CXCL2)

RP-1013 10 ug
EUR 286

Recombinant Mouse (E.Coli) GRO-beta/MIP-2 (CXCL2)

RP-1040 5 ug
EUR 164

CCL4/MIP-1 beta ELISA Kit (Human) (OKBB00368)

OKBB00368 96 Wells
EUR 505
Description: Description of target: Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize MIP-1-beta. the CCL4 gene was assigned to a slightly more distal location: 17q21-q23 rather than 17q11-q21.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 1 pg/mL

CCL4/MIP-1 beta ELISA Kit (Rat) (OKBB00467)

OKBB00467 96 Wells
EUR 505
Description: Description of target: Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in mouse is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize MIP-1-beta. By analysis of somatic cell hybrids and by in situ hybridization, the CCL4 gene was assigned to 17q21-q23. Based on functional analysis of MIP-1β, one or more additional β chemokine receptors that transduce MIP-1β signals must also exist. MIP-1α and MIP-1β have been shown to lack affinity for the erythrocyte surface chemokine receptor/Duffy antigen that binds many α as well as β chemokines (11, 14).;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

b-NGF Beta Nerve Growth Factor Human Recombinant Protein

PROTP01138-3 Regular: 20ug
EUR 317
Description: Nerve Growth Factor-beta Human Recombinant produced in E.Coli is a non-covalently disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2 identical 121 amino acids with a molecular weight of two 13.6 kDa polypeptide monomers.;The NGF-b is purified by proprietary chromatographic techniques.

Anti-MIP-3 alpha Antibody

A00748 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for MIP-3 alpha Antibody (CCL20) detection.tested for IHC in Human, Mouse.

MIP-3/CCL23, human recombinant

7175-10
EUR 207

MIP-3/CCL23, human recombinant

7175-50
EUR 675

MIP-3-alpha/CCL20, Human

HY-P7262 10ug
EUR 268

MIP-3-alpha/CCL20, Mouse

HY-P7263 10ug
EUR 234

MIP-3 alpha, CCL20, human

RC315-31 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

MIP antibody

70R-18519 50 ul
EUR 435
Description: Rabbit polyclonal MIP antibody

MIP Antibody

36125-100ul 100ul
EUR 252

MIP antibody

10R-10490 100 ug
EUR 435
Description: Mouse monoclonal MIP antibody

MIP antibody

10R-10491 100 ug
EUR 435
Description: Mouse monoclonal MIP antibody

MIP Antibody

1-CSB-PA000910
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against MIP. Recognizes MIP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

MIP Antibody

1-CSB-PA884370
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against MIP. Recognizes MIP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:20-1:100

mip Antibody

1-CSB-PA401660HA01LLJ
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against mip. Recognizes mip from Legionella pneumophila. This antibody is Unconjugated. Tested in the following application: ELISA

MIP Antibody

1-CSB-PA283369
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against MIP. Recognizes MIP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

MIP Antibody

1-CSB-PA152107
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against MIP. Recognizes MIP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:500-1:5000, IHC:1:50-1:200

MIP Antibody

1-CSB-PA167583
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against MIP. Recognizes MIP from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

MIP Antibody

1-CSB-PA013834GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
  • Form: Liquid
  • Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles. Antigen Affinity purified
Description: A polyclonal antibody against MIP. Recognizes MIP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

MIP Antibody

1-CSB-PA013834LA01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against MIP. Recognizes MIP from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

MIP-1

EF000186 96 Tests
EUR 689

MIP-1

EF016834 96 Tests
EUR 689

MIP-1

EF017045 96 Tests
EUR 689

MIP-1

EF017887 96 Tests
EUR 689

MIP-1

EF013758 96 Tests
EUR 689

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